compound 6ee [PMID: 22364528]

Ligand id: 8796

Name: compound 6ee [PMID: 22364528]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 126.56
Molecular weight 587.25
XLogP 5.34
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
egl-9 family hypoxia inducible factor 2 Inhibitor Inhibition 9.7 pIC50 - 1
pIC50 9.7 (IC50 2x10-10 M) [1]
egl-9 family hypoxia inducible factor 1 Inhibitor Inhibition 9.7 pIC50 - 1
pIC50 9.7 (IC50 2x10-10 M) [1]
egl-9 family hypoxia inducible factor 3 Inhibitor Inhibition 8.5 pIC50 - 1
pIC50 8.5 (IC50 3.5x10-9 M) [1]