compound 10 [PMID: 18759424]

Ligand id: 8838

Name: compound 10 [PMID: 18759424]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 57.53
Molecular weight 436.18
XLogP 9.16
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
It is reported that binding of compound 10 to SHP correlates with induction of apoptosis in vitro. In addition, compound 10 inhibits SHP-2 (protein tyrosine phosphatase, non-receptor type 11, PTPN11) activity with an IC50 of 2270nM [1].
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
SHP Hs None Binding 6.3 pIC50 - 1
pIC50 6.3 (IC50 5x10-7 M) [1]