Ligand id: 8945

Name: CCT251545

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 63.05
Molecular weight 421.17
XLogP 2.9
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
CCT251545 inhibits CDK8-mediated STAT1 phosphorylation in vitro in human colorectal cancer cell lines, and reverses experimental intestinal hyperplasia in WNT-dependent tumour models in vivo [1].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
cyclin dependent kinase 19 Hs Inhibitor Inhibition 8.6 pKd - 1
pKd 8.6 (Kd 2.54x10-9 M) [1]
Description: CDK19/cyclin C.
cyclin dependent kinase 8 Hs Inhibitor Inhibition 8.4 pKd - 1
pKd 8.4 (Kd 3.8x10-9 M) [1]
Description: CDK8/cyclin C.