Ligand id: 8950

Name: BI-9564

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 54.9
Molecular weight 353.17
XLogP 1.27
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
BI-9564 shows off-target selectivity to CECR2 in biochemical assays but not in cellular assays.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
bromodomain containing 9 Hs Inhibitor Inhibition 7.8 pKd - 3
pKd 7.8 (Kd 1.4x10-8 M) [3]
bromodomain containing 7 Hs Inhibitor Inhibition 6.6 pKd - 3
pKd 6.6 (Kd 2.39x10-7 M) [3]