AZ10606120

Ligand id: 9021

Name: AZ10606120

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 10
Topological polar surface area 86.28
Molecular weight 422.27
XLogP 4.97
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Guille et al. (2009) [2] report this compound as an antagonist of the P2X7 receptor.
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
P2X7 Hs Antagonist Antagonist 8.9 pKd - 3
pKd 8.9 (Kd 1.4x10-9 M) [3]
Description: Measuring binding of [3H]-AZ10606120 to human P2X7 receptors
P2X7 Rn Antagonist Antagonist 8.7 pKd - 3
pKd 8.7 (Kd 1.9x10-9 M) [3]
Description: Measuring binding of [3H]-AZ10606120 to rat P2X7 receptors
P2X7 Hs Allosteric modulator Negative - - - 3
[3]
[3]