Ligand id: 9079

Name: MRL-367

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 102.56
Molecular weight 481.05
XLogP 4.91
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Bioactivity Comments
In a RORγ/Gal4 cell-based reporter assay MRL-367 inhibits RORγt with an IC50 of 41nM, and shows no significant activity against a panel of related nuclear hormone receptors [1].