Ligand id: 9115

Name: CPI-1205

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 75.6
Molecular weight 518.25
XLogP 5.52
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Cellular EC50 is 32 nM [4].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
enhancer of zeste 2 polycomb repressive complex 2 subunit Hs Inhibitor Inhibition 8.7 pIC50 - 4
pIC50 8.7 (IC50 2x10-9 M) [4]
Description: Cell-free biochemical assay