compound 34h [PMID: 27055065]

Ligand id: 9169

Name: compound 34h [PMID: 27055065]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 89.78
Molecular weight 431.24
XLogP 3.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
In a kinase profile screen 1μM compound 34h inhibited TNK2, JNK1, JNK2, and LRRK by >80% and it is devoid of CYP or hERG liability [2].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
TTK protein kinase Hs Inhibitor Inhibition 8.0 – 8.3 pIC50 - 1-2
pIC50 8.0 – 8.3 (IC50 1.1x10-8 – 5x10-9 M) [1-2]