urocortin 1   Click here for help

GtoPdb Ligand ID: 920

Comment: The human UCN sequence differs from the mouse and rat sequences at residues 2 and 4 representing asparagine and serine, respectively. The mouse and rat sequences are identical.
Species: Mouse, Rat
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Natural/Endogenous Targets
Target
CRF1 receptor
CRF2 receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CRF1 receptor Hs Agonist Full agonist 8.3 – 9.8 pKd - 1-5
pKd 8.3 – 9.8 [1-5]
CRF2 receptor Hs Agonist Full agonist 8.6 – 9.4 pKd - 1
pKd 8.6 – 9.4 [1]