Ligand id: 9359

Name: CP466722

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 113.86
Molecular weight 349.13
XLogP 1.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
CP466722-induced disruption of ATM inhibits ATM-dependent phosphorylation events which results in cell cycle checkpoint defects. ATM inhibition has a radiosensitization effect in vitro [1]. CP466722 does not inhibit PI3K or closely related PI3K-like protein kinases (PIKKs), but inhibitory activities against Abl and Src kinases suggest these may be off-targets.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
ATM serine/threonine kinase Hs Inhibitor Inhibition - - - 1