CX-5011

Ligand id: 9373

Name: CX-5011

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 90.83
Molecular weight 339.09
XLogP 3.19
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
CX-5011 is minimally inhibitory for PIM1, a common off-target affected by previous CK2 inhibitors. CX-5011 has antiproliferative effect at low namomolar concentration across a wide range of cancer cell lines [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Casein kinase 2 Inhibitor Inhibition 8.6 pIC50 - 1
pIC50 8.6 (IC50 2.3x10-9 M) [1]
Description: Recombinant holoenzyme with wild-type alpha subunits.
Pim-1 proto-oncogene, serine/threonine kinase Inhibitor Inhibition 5.6 pIC50 - 1
pIC50 5.6 (IC50 2.51x10-6 M) [1]
Selectivity at rat enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Casein kinase 2 Inhibitor Inhibition 9.0 pIC50 - 1
pIC50 9.0 (IC50 9.7x10-10 M) [1]
Description: Native rat CK2 isolated from liver.