DAPK inhibitor 13

Ligand id: 9422

Name: DAPK inhibitor 13

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 51.55
Molecular weight 342
XLogP 4.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
DAPK inhibitor 13 (10μM) inhibits DAPK2 by ~40% [1], DAPK3 by 98% and DAPK1 by 82% (both at 10μM) [2]. Inhibition of DAPK3 falls to 88% at 1μM.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
death associated protein kinase 3 Hs Inhibitor Inhibition 6.6 pIC50 - 2
pIC50 6.6 (IC50 2.53x10-7 M) [2]