AZ8838

Ligand id: 9585

Name: AZ8838

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 48.91
Molecular weight 234.12
XLogP 3.02
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
PAR2 Antagonist Antagonist 6.5 pKd - 1
pKd 6.5 (Kd 3.44x10-7 M) [1]
Description: Saturation binding of [3H]-AZ8838 antagonist to wild-type PAR2.
PAR2 Antagonist Antagonist 5.6 – 5.8 pIC50 - 1
pIC50 5.8 (IC50 1.5x10-6 M) [1]
Description: Measuring SLIGRL-NH2-induced IP1 formation
pIC50 5.6 (IC50 2.3x10-6 M) [1]
Description: In a FLIPR assay measuring SLIGRL-NH2-induced calcium mobilisation.