Plasmodium falciparum N-myristoyltransferase
|
|
|
|
Parasite growth inhibition assay |
- |
- |
6.6 |
pEC50 |
- |
2 |
|
⤷ |
pEC50
6.6
(EC50 2.32x10-7 M)
[3H]-hypoxanthine incorporation
[2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Plasmodium falciparum N-myristoyltransferase
|
|
|
|
Parasite growth inhibition assay |
- |
- |
6.5 |
pEC50 |
- |
2 |
|
⤷ |
pEC50
6.5
(EC50 3.02x10-7 M)
[3H]-hypoxanthine incorporation
[2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Plasmodium falciparum N-myristoyltransferase
|
|
|
|
Parasite growth inhibition assay |
- |
- |
6.5 |
pEC50 |
- |
2 |
|
⤷ |
pEC50
6.5
(EC50 3.39x10-7 M)
[3H]-hypoxanthine incorporation
[2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Plasmodium falciparum N-myristoyltransferase
|
|
|
|
Parasite liver stage assay |
- |
- |
6.4 |
pEC50 |
- |
2 |
|
⤷ |
pEC50
6.4
(EC50 3.72x10-7 M)
Luciferase bioluminescence assay to measure viability of exoerythrocytic forms (EEF)
[2]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
|
Plasmodium falciparum N-myristoyltransferase
|
|
|
|
Parasite growth inhibition assay |
- |
- |
6.0 |
pEC50 |
- |
2 |
|
⤷ |
pEC50
6.0
(EC50 9.16x10-7 M)
[3H]-hypoxanthine incorporation
[2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|