zotepine

Ligand id: 103

Name: zotepine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 37.77
Molecular weight 331.08
XLogP 5.18
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat schizophrenia.
This drug is not approved for use in the UK or the US. Other national approval agencies may have granted marketing authorisation. The FDA website lists Japan, Taiwan, Indonesia, South Korea, Bulgaria, Czech Republic, Lithuania, Portugal and Germany as international markets for zotepine.
Mechanism Of Action and Pharmacodynamic Effects
Zopetine is a dual function antagonist of dopamine and serotonin receptors. Reducing the activity of these receptors effects improvement of psychotic symptoms and mania.