daridorexant   Click here for help

GtoPdb Ligand ID: 11648

Synonyms: ACT-541468 | ACT541468 | nemorexant (former name) | Quviviq®
Approved drug PDB Ligand
daridorexant is an approved drug (FDA & EMA (2022))
Compound class: Synthetic organic
Comment: Daridorexant (ACT-541468) is a dual orexin receptor antagonist [4-5]. It was designed and developed for potential to treat insomnia [1-3,7-8].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 88.41
Molecular weight 450.16
XLogP 4.57
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES COc1ccc(c(c1)C(=O)N1CCC[C@@]1(C)c1nc2c([nH]1)ccc(c2C)Cl)n1nccn1
Isomeric SMILES Cc1c(ccc2c1nc([nH]2)[C@@]1(CCCN1C(=O)c1c(ccc(c1)OC)n1nccn1)C)Cl
InChI InChI=1S/C23H23ClN6O2/c1-14-17(24)6-7-18-20(14)28-22(27-18)23(2)9-4-12-29(23)21(31)16-13-15(32-3)5-8-19(16)30-25-10-11-26-30/h5-8,10-11,13H,4,9,12H2,1-3H3,(H,27,28)/t23-/m0/s1
InChI Key NBGABHGMJVIVBW-QHCPKHFHSA-N
No information available.
Summary of Clinical Use Click here for help
Daridorexant (ACT-541468) was progressed through clinical evaluation as a sleep-promoting agent. Its first approval was granted by the FDA in January 2022. Under this authorisation daridorexant is indicated to treat insomnia that is characterised by difficulties with sleep onset and/or sleep maintenance.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT02839200 Efficacy and Safety of ACT-541468 in Adult Subjects With Insomnia Disorder Phase 2 Interventional Idorsia Pharmaceuticals Ltd. 1
NCT03545191 Study to Assess the Efficacy and Safety of ACT-541468 in Adult and Elderly Subjects With Insomnia Disorder Phase 3 Interventional Idorsia Pharmaceuticals Ltd.