Ligand id: 121

Name: dihydroergotamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 118.21
Molecular weight 583.28
XLogP 4.17
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Dihydroergotamine is used to treat migraine and cluster headaches.
Mechanism Of Action and Pharmacodynamic Effects
The anti-migraine activity of dihydroergotamine is believed to be due to its high affinity binding to serotonin 5-HT1D receptors on intracranial blood vessels (causes vasoconstriction and headache relief) and on sensory nerve endings of the trigeminal system (inhibits release of pro-inflammatory neuropeptides)
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