Ligand id: 1224

Name: diphenhydramine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 12.47
Molecular weight 255.16
XLogP 5.73
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Diphenhydramine is a histamine antagonist, but is often used for its antiemetic effects to treat conditions such as vertigo, nausea and vomiting and motion sickness. It is also used to treat hypersensitivity reactions and irritant coughs. Diphenhydramine is an ingredient in some common cold preparations, but does cause undesirable drowsiness.
Mechanism Of Action and Pharmacodynamic Effects
In addition to anti-histaminergic actions, diphenhydramine also has antimuscarinic/anticholinergic action which is believed to account for both the drowsiness side-effect and also for the beneficial antiemetic and antidyskinesia (ie may help with movement disorders such as parkansinism) effects.