triprolidine

Ligand id: 1228

Name: triprolidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 16.13
Molecular weight 278.18
XLogP 5.94
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used for the symptomatic relief of seasonal or perennial allergic rhinitis or nonallergic rhinitis, allergic conjunctivitis and mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Marketing of the brand Actidil® has been discontinued in the US.
Mechanism Of Action and Pharmacodynamic Effects
Binds to the histamine H1 receptor, blocking the action of endogenous histamine, leading to the temporary relief of symptoms induced by histamine agonism of the receptors.
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