Ligand id: 1231

Name: cimetidine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 114.19
Molecular weight 252.12
XLogP 1.27
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Cimetidine is used to treat and/or manage acid-reflux disorders, peptic ulcers, heartburn, and acid indigestion.
Mechanism Of Action and Pharmacodynamic Effects
By antagonising the activity of the histamine H2 receptor, cimetidine inhibits the secretion of gastric acid (and reduces acidity) from the parietal cells of the stomach lining.
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