brodimoprim   Click here for help

GtoPdb Ligand ID: 12325

Synonyms: Ro 10-5970
Compound class: Synthetic organic
Comment: Brodimoprim belongs to the diaminopyrimidine class of compounds and is a structural analogue of trimethoprim. It inhibits bacterial dihydrofolate reductase (DHFR) and has antibacterial and antiprotozoal activities [3].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 96.28
Molecular weight 338.04
XLogP 1.93
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES COc1cc(Cc2cnc(nc2N)N)cc(c1Br)OC
Isomeric SMILES COc1cc(cc(c1Br)OC)Cc1cnc(nc1N)N
InChI InChI=1S/C13H15BrN4O2/c1-19-9-4-7(5-10(20-2)11(9)14)3-8-6-17-13(16)18-12(8)15/h4-6H,3H2,1-2H3,(H4,15,16,17,18)
InChI Key BFCRRLMMHNLSCP-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Brodimoprim has been clinically evaluated in the treatment of urinary tract infections and acute sinusitis [1-2].
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Mechanistically, it inhibits bacterial dihydrofolate reductase and disrupts the conversion of dihydrofolic acid to tetrahydrofolic acid which ultimately inhibits bacterial DNA synthesis.