Synonyms: sulfanilylguanidine | sulphaguanidine
sulfaguanidine is an approved drug (FDA (1941))
Compound class:
Synthetic organic
Comment: Sulfaguanidine is a sulfonamide antimicrobial compound [4]. Structurally it is a guanidine derivative of sulfanilamide.
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No information available. |
Summary of Clinical Use |
Sulfaguanidine has been marketed in a number of jurisdictions, including the US, Japan and some European countries. However, there is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency (EMA) websites. Individual national approval agencies may have granted marketing authorisation. The international drug listing on the FDA website states that in some countries sulfaguanidine may only be approved for veterinary use. |
Mechanism Of Action and Pharmacodynamic Effects |
Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants [2]. The antibacterial MMOA is competitive inhibition of bacterial dihydropteroate synthase (DHPS) resulting in a block of folate biosynthesis [1]. |