sulfathiazole   Click here for help

GtoPdb Ligand ID: 12699

Synonyms: M&B 760 | Thiazamide®
Approved drug PDB Ligand
sulfathiazole is an approved drug (FDA (1945))
Compound class: Synthetic organic
Comment: Sulfathiazole is a sulfonamide antibacterial compound [5].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 118.23
Molecular weight 255.32
XLogP -0.46
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C1=C(C=CC(=C1)S(=O)(=O)NC2=NC=CS2)N
Isomeric SMILES C1=CC(=CC=C1N)S(=O)(=O)NC2=NC=CS2
InChI InChI=1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)
InChI Key JNMRHUJNCSQMMB-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
All medicines containing sulfathiazole (except for those formulated for vaginal use) were withdrawn by the US FDA in 1970, due to associated renal complications, rash, fever, blood disorders, and liver damage. There is no information regarding current approval for clinical use of this drug on the European Medicines Agency (EMA) website, although individual European agencies have authorised its use. See the Drugs.com website for a list of countries where this drug may be in use (in some, this may be restricted to veterinary practice).
Sulfathiazole can be used in combination with sulfabenzamide and sulfacetamide (formulated for vaginal administration). The combined formulation was approved by the US FDA, but has since been discontinued.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants [2]. The antibacterial MMOA is competitive inhibition of bacterial dihydropteroate synthase (DHPS) resulting in a block of folate biosynthesis [1].