Synonyms: SBT-272 | SBT272
Compound class:
Peptide or derivative
Comment: Bevemipretide is a modified tripeptide (H-DArg-2,6-diMeTyr-Unk, from PubChem) that helps to stabilise the cardiolipin-rich inner mitochondrial membrane and promotes antioxidant, neuroprotective and mitochondria-protective effects in upper motor neurons (UMNs) [1].
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No information available. |
Summary of Clinical Use |
Stealth BioTherapeutics advanced bevemipretide (SBT-272) to early clinical evaluation in 2020 to determine safety and tolerability. It was intended to restore neuronal mitochondrial structure and function in neurodegenerative diseases involving mitochondrial dysfunction. The compound was granted FDA orphan drug status in March 2022 as a treatment for amyotrophic lateral sclerosis (ALS; a.k.a. motor neuron disease or MND). In March 2024, there was no evidence of active SBT-272 clinical trials on ClinicalTrials.gov. |