Ligand id: 149

Name: ergotamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 118.21
Molecular weight 581.26
XLogP 3.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Vasoconstrictor, used in the treatment of acute migraine.
Mechanism Of Action and Pharmacodynamic Effects
Ergotamine shares structural similarity with neurotransmitters such as serotonin, dopamine, and epinephrine and is therefore an agonist of several receptors. Ergotamine causes vasoconstriction and inhibits the release of pro-inflammatory neuropeptides which correlate with relief of migraine symptoms.