Ligand id: 150

Name: methylergonovine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 68.36
Molecular weight 339.19
XLogP 1.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the prevention of excessive bleeding after childbirth.
Mechanism Of Action and Pharmacodynamic Effects
This drug appears to have multiple molecular targets, including adrenoceptors, dopamine receptors, and 5-HT receptors, although the exact mechanism of action remains unclear. Through antagonism of the dopamine D1 receptor in the smooth muscle of the uterus methylergonovine increases the tone, rate and amplitude of contractions which leads to the third stage of labour being shortened and blood loss being reduced.