Ligand id: 1670

Name: buprenorphine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 62.16
Molecular weight 467.3
XLogP 3.87
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat severe pain and to ameliorate opioid dependence.
Probuphine®, the first buprenorphine implant for the maintenance treatment of opioid dependence was US FDA approved in May 2016.
Mechanism Of Action and Pharmacodynamic Effects
Buprenorphine appears to act as a partial agonist at μ- and κ-opioid receptors and as an antagonist at δ-opioid receptors.