latanoprost (free acid form)

Ligand id: 1960

Name: latanoprost (free acid form)

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 12
Topological polar surface area 97.99
Molecular weight 390.24
XLogP 5.23
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Lantanoprost is admisistered as a prodrug as an opthalmic solution applied topically to the eye to control the progression of glaucoma or ocular hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Once metabolised to its active free acid form in vivo, latanoprost is a selective agonist of the FP receptor. This agonism results in a reduction in interocular pressure by means of increased outflow of aqueous fluid from the eyes.