agomelatine

Ligand id: 198

Name: agomelatine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 38.33
Molecular weight 243.13
XLogP 3.78
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of major depressive disorder.
Mechanism Of Action and Pharmacodynamic Effects
Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin 5-HT2C receptors. The drug induces noradrenaline and dopamine release in the frontal cortex and the melatonergic effects of agomelatine appear to resynchronise circadian rhythms, thus inducing a phase advance of sleep. It is postulated that the synergy between these two systems is responsible for the drug's psychotropic effects [3].
External links