Ligand id: 202

Name: duloxetine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 49.5
Molecular weight 297.12
XLogP 5.83
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Duloxetine is primarily used to treat major depressive and general anxiety disorders. Duloxetine is also used to treat chronic pain conditions such as fibromyalgia, chronic low back and osteoarthritis pain and diabetic neuropathy. Prescription formulations contain duloxetine hydrochloride (PubChem CID 608340.
Mechanism Of Action and Pharmacodynamic Effects
Duloxetine is a potent inhibitor of neuronal serotonin (5-HT) and norepinephrine reuptake via the transporters SLC6A4 the SLC6A2 respectively. The pain inhibitory effect is believed to be due to the ablility of duloxetine to potentiate serotonergic and noradrenergic activity in the central nervous system.
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