tegaserod

Ligand id: 226

Name: tegaserod

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 84.03
Molecular weight 301.19
XLogP 3.69
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Tegaserod was approved by the FDA in 2002 for the management of irritable bowel syndrome and constipation, but later withdrawn in 2007 due to concerns surrounding cardiovascular effects.
Mechanism Of Action and Pharmacodynamic Effects
Tegaserod is a 5-HT4 receptor agonist. Tegaserod-induced activation of 5-HT4 receptors expressed in the gastrointestinal tract stimulates the peristaltic reflex and hence, improves gut motility.