Ligand id: 2376

Name: pregnenolone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 37.3
Molecular weight 316.24
XLogP 4.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
In the brain pregnenolone acts as a neurosteroid [3-4] with synaptic function, neuroprotective and myelinization enhancing properties. Based on this activity pregnenolone and its sulphate ester (PubChem CID 105074) have been investigated as potential nootropics [5], and pregnenolone was also considered as an anti-schizophrenic [3].
The only clinical approval for pregnenolone appears to be a combination formulation with androstenedione available in Japan.
Mechanism Of Action and Pharmacodynamic Effects
Pregnenolone sulfate has been reported to act as an activator of the TRPM1 and TRPM3 channels [1].