Ligand id: 2398

Name: clomipramine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 6.48
Molecular weight 314.15
XLogP 5.13
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Clomipramine is used to treat symptoms of major depressive disorder, obsessive-compulsive disorder (OCD), schizophrenia and Tourette’s disorder, panic disorder and cataplexy in narcolepsy. In patients with depression clomipramine exerts a positive effect on mood.
Mechanism Of Action and Pharmacodynamic Effects
Clomipramine inhibits the sodium-dependent serotonin transporter (SLC6A4).