desipramine

Ligand id: 2399

Name: desipramine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 15.27
Molecular weight 266.18
XLogP 5.01
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Desipramine is used to treat major depressive disorder. The drug exerts a positive effect on mood in patients suffering from depression. Off-label uses include treatment of neuropathic pain, agitation and insomnia and attention-deficit hyperactivity disorder (ADHD).
Mechanism Of Action and Pharmacodynamic Effects
The antidepressant effects of drugs such as desipramine are postulated to be due to an overall increase in serotonergic neurotransmission, via inhibition of SLC6A2 (norepinephrine transporter). Side effects may arise from activity at other targets such as the histamine H1 receptor, the α1-adrenergic receptor and muscarinic receptors.