maprotiline

Ligand id: 2402

Name: maprotiline

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 12.03
Molecular weight 277.18
XLogP 8.58
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of depression, including major depressive disorder, bipolar depression, psychotic depression, and involutional melancholia.
Mechanism Of Action and Pharmacodynamic Effects
Maprotiline is a potent norepinephrine reuptake inhibitor. It only weakly inhibits serotonin and dopamine reuptake. Receptor pharmacology: potent antagonist of the histamine H1 and serotonin 5-HT7 receptors; moderate antagonist of the serotonin 5-HT2 and α1-adrenoceptors; weak antagonist of the dopamine D2 and metabotropic acetylcholine receptors.
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