econazole

Ligand id: 2446

Name: econazole

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 27.05
Molecular weight 380.02
XLogP 4.82
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Topically applied econazole is used to treat fungal skin infections such as athlete's foot, ringworm, tinea versicolor, and yeast infections.
Mechanism Of Action and Pharmacodynamic Effects
Econazole interacts with 14-α demethylase (cytochrome P450 51 ), an enzyme required to convert lanosterol to ergosterol, an essential component of the fungal cell membrane. This disrupts fungal cell wall formation and results in cell death.