miconazole

Ligand id: 2449

Name: miconazole

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 27.05
Molecular weight 413.99
XLogP 4.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.
Mechanism Of Action and Pharmacodynamic Effects
Inhibits the cytochrome p-450 enzyme 14-α demethylase enzyme, inhibiting the conversion of lanosterol to fungal cell wall component ergosterol. This inhibition therefore results in increased cellular permeability leading to leakage of the cellular contents.