ketoconazole

Ligand id: 2568

Name: ketoconazole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 69.06
Molecular weight 530.15
XLogP 3.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of systemic fungal conditions, namely candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
Mechanism Of Action and Pharmacodynamic Effects
Inhibitor of fungal enzyme 14-α demethylase, one of the cytochrome P-450 enzymes. This inhibits the conversion of lanosterol to ergosterol, leading to increased fungal cell permeability.