Ligand id: 2623

Name: lidocaine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 32.34
Molecular weight 234.17
XLogP 2.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the production of local and regional anaesthesia.
Mechanism Of Action and Pharmacodynamic Effects
Lidocaine blocks voltage-gated sodium channels in neuronal cell membranes thereby inhibiting ionic influxes and subsequent signal propagation, leading to a local anaesthetic effect.