Ligand id: 2645

Name: alitretinoin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 37.3
Molecular weight 300.21
XLogP 6.25
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat severe chronic hand eczema refractory to potent topical corticosteroids.
Mechanism Of Action and Pharmacodynamic Effects
Alitretinoin binds and activates all known intracellular retinoid receptor subtypes. Activated retinoic acid receptors act as transcription factors regulating genes that control cellular differentiation and proliferation in normal and neoplastic cells.