Ligand id: 2667

Name: clofibrate

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: clofibrate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 35.53
Molecular weight 242.07
XLogP 3.21
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Clofibrate is an antilipidemic agent. It acts to lower elevated serum lipids and may therfore be used to treat conditions causing high cholesterol and high triglyceride levels, such as hyperlipoproteinemia type III and severe hypertriglyceridemia.
Mechanism Of Action and Pharmacodynamic Effects
Clofibrate is a peroxisome proliferator-activated receptor alpha (PPARA) agonist in muscle, liver, and other tissues, activation of which leads to altered gene expression resulting in increased beta-oxidation, decreased triglyceride secretion, increased HDL and increased lipoprotein lipase activity.