mesalazine

Ligand id: 2700

Name: mesalazine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 83.55
Molecular weight 153.04
XLogP 0.47
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of active ulcerative proctitis. There is no information regarding approval for medical use of mesalazine on the US FDA website. Individual national agencies may have granted marketing approval.
Mechanism Of Action and Pharmacodynamic Effects
The exact mechanism of action of mesalazine is unknown, but is believed to be derived from inhibition of cyclooxygenase and prostaglandin production in the colon.