mesalazine

Ligand id: 2700

Name: mesalazine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 83.55
Molecular weight 153.04
XLogP 0.47
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Mesalazine is used to treat active ulcerative colitis and to prevent symptom recurrence. It may also be used for the management of other types of inflammatory bowel disease (e.g. Crohn's disease).
Mechanism Of Action and Pharmacodynamic Effects
The exact mechanism of action of mesalazine is unknown, but is believed to be derived from inhibition of cyclooxygenase and prostaglandin production in the colon. Its action is believed to be topical rather than systemic.
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