mifepristone

Ligand id: 2805

Name: mifepristone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 40.54
Molecular weight 429.27
XLogP 4.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
As a progesterone receptor antagonist this drug is used to induce medical termination of pregnancy (<49 days gestation). As a glucocorticoid receptor antagonist, this drug may be used in certain patients to treat hypercortisolism associated with nonpituitary Cushing's syndrome.
Mechanism Of Action and Pharmacodynamic Effects
Mifepristone competitively binds to the progesterone receptor, which inhibits the activity of progesterone.