Ligand id: 2818

Name: estrone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 37.3
Molecular weight 270.16
XLogP 4.04
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Estrone is used to manage peri- and post-menopausal symptoms, importantly estrogen deficiency-induced osteoporosis. Estrone does not appear to have general US FDA or European Medicines Agency marketing approval, although a few national agencies approve this drug.
Mechanism Of Action and Pharmacodynamic Effects
Estrone binding to estrogen receptor α, creates a transcription factor which binds to estrogen response elements in target gene promoter regions leading to estrogen-regulated protein synthesis.