estriol

Ligand id: 2821

Name: estriol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 3
Rotatable bonds 0
Topological polar surface area 60.69
Molecular weight 288.17
XLogP 4.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
The US FDA does not approve marketing of estriol, although this compound has been approved and marketed in Europe and Asia for >40 years for the treatment of post-menopausal hot flashes.
Mechanism Of Action and Pharmacodynamic Effects
Estriol binds to its the estrogen receptor α, acting as a transcription factor to target gene transcription and protein synthesis.