Ligand id: 2864

Name: nilutamide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 92.55
Molecular weight 317.06
XLogP 3.22
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Antineoplastic hormonal agent used in the treatment of prostate cancer.
Mechanism Of Action and Pharmacodynamic Effects
Antagonist of androgen receptors, by competing with the binding of androgen. This blocks the actions of androgens that stimulate the growth of normal and malignant prostatic tissue through the inhbition of androgen-dependent DNA and protein synthesis.
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