eplerenone

Ligand id: 2876

Name: eplerenone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 82.2
Molecular weight 414.2
XLogP 1.32
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Eplerenone is used to treat patients with left ventricular systolic dysfunction and those developing congestive heart failure after a heart attack.
Mechanism Of Action and Pharmacodynamic Effects
Eplerenone modulates the renin-angiotensin-aldosterone-system and increases blood pressure by several potential routes, including induction of sodium reabsorption.