Ligand id: 2879

Name: medroxyprogesterone

Abbreviated name: MPA

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: medroxyprogesterone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 54.37
Molecular weight 344.24
XLogP 3.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as a contraceptive and also to treat abnormal uterine conditions. Aditionally used to treat GnRH-dependent forms of precocious puberty.
Mechanism Of Action and Pharmacodynamic Effects
This synthetic progestin mimics the actions of progesterone with greater potency. Binds to the progesterone receptor in cells which has the effect of slowing the release of gonadotrophin releasing hormone from the hypothalamus and blunts the pre-ovulatory LH surge.