Ligand id: 2880

Name: norethisterone

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View more information in the IUPHAR Pharmacology Education Project: norethisterone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 37.3
Molecular weight 298.19
XLogP 3.24
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as a contraceptive and to treat menstrual disorders such as endometriosis, or abnormal vaginal bleeding caused by a hormone imbalance.
Mechanism Of Action and Pharmacodynamic Effects
Synthetic progestin and agonist of the progesterone receptor. Once bound to the receptor, norethisterone slows the frequency of the pulsatile release of GnRH from the hypothalamus and blunts the pre-ovulatory surge of LH.
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