levonorgestrel

Ligand id: 2881

Name: levonorgestrel

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View more information in the IUPHAR Pharmacology Education Project: levonorgestrel

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 37.3
Molecular weight 312.21
XLogP 3.81
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
A contraceptive, also used in the treatment of menstrual disorders and endometriosis, levonorgestrel is the active component of the approved drug norgestrel.
Mechanism Of Action and Pharmacodynamic Effects
A synthetic progestin which binds to the progesterone and estrogen receptors, slowing the frequency of release of gonadotrophin releasing hormone from the hypothalamus and reducing the surge of LH before ovulation.